P504S

P504S, also known as α-methylacyl coenzyme A racemase (AMACR), is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β-oxidation of branched chain fatty acids. P504S was initially identified from a cDNA library as a gene that is overexpressed in human prostate cancer; with little or no expression in normal prostate. In immunohistochemistry, P504S (P) antibody has been shown to be a specific marker of prostatic adenocarcinoma. Additionally, prostate glands involved in PIN have been found to express P504S, whereas P504S was nearly undetectable in benign glands.

Specifications

1. Ferdinandusse S, et. al. Subcellular localization and physiological role of α-
methylacyl-CoA racemase. J Lipid Res. 2000; 41:1890-6.
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Cancer Using Subtraction and Microarray. Cancer Res. 2000; 60:1677-82.
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Prostate Cancer. JAMA. 2002; 287:1662-70.
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cancer. Cancer Res. 2002; 62:2220-6.
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Overexpressed in Several Human Cancers and Their Precursor Lesions. Am J Surg
Pathol. 2002; 26:926-31.
6. Wu CL, et. al. Analysis of α-Methylacyl-CoA Racemase (P504S) Expression in
High-Grade Prostatic Intraepithelial Neoplasia. Hum Pathol. 2004; 35:1008-13.
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