Description
The human carcinoembryonic antigen antibody (CEA) family consists of glycophosphatidyl inositol (GPI) linkage and transmembrane linkage members. Studies suggest the GPI-linked members tend to be up regulated in human tumors, whereas the transmembrane-linked members tend to be down regulated. CEA (CD66e) [COL-1], a GPI-linked member, shows no detectable reactivity for other CEA members. [COL-1] may be useful in aiding the detection of early foci of gastric carcinoma and distinguishing pulmonary adenocarcinomas from mesothelioma. Studies have shown it stains many types of adenocarcinoma, but does not stain benign glands, stroma, or malignant prostatic cells.
SPECIFICATIONS
Specifications
| WEIGHT | N/A |
|---|---|
| DIMENSIONS | N/A |
| INTENDED USE | IVD |
| SPECIES REACTIVITY | Human |
| SOURCE | Mouse Monoclonal |
| CLONE | COL-1 |
| ISOTYPE | CEA |
| ANTIGEN | CEA |
| LOCALIZATION | Cytoplasmic and Lumenal Membrane |
| POSITIVE CONTROL | Colon Carcinoma |
DATASHEETS & SDS
INTERNATIONAL
REFERENCES
1. Luo W, et al. Oncogene. 1998 Mar; 16(9):1141-7.
2. Obrink B. Curr Opin Cell Biol. 1997 Oct; 9(5):616-26.
3. Screaton RA, Penn LZ, Stanners CP. J Cell Biol. 1997 May; 137(4):939-52.
4. Nollau P, et al. Cancer Res. 1997 Jun; 57(12):2354-57.
5. Rojas M, et al. Cell Growth Differ. 1996 May; 7(5):655-62.
6. Shi ZR, Tacha D, Itzkowitz SH. J Histochem Cytochem. 1994 Sep; 42(9):1215-9.
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